2252247-80-4
2252247-80-4
Chemical Structure
SHIP2-IN-1
- CAS No.: 2252247-80-4
- Formula:C17H13Cl2FN4O
- Molecular Weight:379.22
IUPAC Name: (R)-5-(5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)pyrimidin-2-amine
InChIKey: ATPYDXUUBCDYKQ-SECBINFHSA-N
SMILES: FC1=C(Cl)C([C@@H](C)OC2=CN=CC(C3=CN=C(N)N=C3)=C2)=C(Cl)C=C1
Biological Activity: SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 μM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SHIP2-IN-1 | 98.66% | SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 μM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.60
HY-75470R(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine (Standard) -
Similarity Score 0.59
HY-100549R(S)-Crizotinib (Standard) -
Similarity Score 0.59
HY-50878RCrizotinib (Standard) -
Similarity Score 0.58
HY-50878ACrizotinib hydrochloride -
Similarity Score 0.57
HY-133202-Keto Crizotinib -
Similarity Score 0.57
HY-75468crizotinib impurity 1 -
Similarity Score 0.57
HY-50878BCrizotinib acetate -
Similarity Score 0.53
HY-125012MAP4K4-IN-3 -
Similarity Score 0.52
HY-144279MsbA-IN-1 -
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