crizotinib impurity 1

Cat. No.: HY-75468 Purity: 99.58%: Data Sheet
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Handling Instructions
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Crizotinib impurity 1 is an impurity of Crizotinib (HY-50878).

For research use only. We do not sell to patients.

crizotinib impurity 1 Chemical Structure

CAS No. : 877397-70-1

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

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Other Forms of crizotinib impurity 1:

crizotinib impurity 1 (Standard) Get quote

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Description

Crizotinib impurity 1 is an impurity of Crizotinib (HY-50878).

Molecular Weight

331.13

Formula

C₁₃H₉Cl₂FN₂O₃

CAS No.

877397-70-1

Appearance

Solid

SMILES

FC1=C(C([C@@H](C)OC2=C([N+]([O-])=O)N=CC=C2)=C(Cl)C=C1)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (302.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0200 mL	15.0998 mL	30.1996 mL
5 mM	0.6040 mL	3.0200 mL	6.0399 mL
10 mM	0.3020 mL	1.5100 mL	3.0200 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.94%

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Data Sheet (250 KB) SDS (396 KB)

COA (258 KB) HNMR (116 KB) RP-HPLC (211 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0200 mL	15.0998 mL	30.1996 mL	75.4990 mL
	5 mM	0.6040 mL	3.0200 mL	6.0399 mL	15.0998 mL
	10 mM	0.3020 mL	1.5100 mL	3.0200 mL	7.5499 mL
	15 mM	0.2013 mL	1.0067 mL	2.0133 mL	5.0333 mL
	20 mM	0.1510 mL	0.7550 mL	1.5100 mL	3.7750 mL
	25 mM	0.1208 mL	0.6040 mL	1.2080 mL	3.0200 mL
	30 mM	0.1007 mL	0.5033 mL	1.0067 mL	2.5166 mL
	40 mM	0.0755 mL	0.3775 mL	0.7550 mL	1.8875 mL
	50 mM	0.0604 mL	0.3020 mL	0.6040 mL	1.5100 mL
	60 mM	0.0503 mL	0.2517 mL	0.5033 mL	1.2583 mL
	80 mM	0.0377 mL	0.1887 mL	0.3775 mL	0.9437 mL
	100 mM	0.0302 mL	0.1510 mL	0.3020 mL	0.7550 mL