2254432-75-0
2254432-75-0
Chemical Structure
NLRP3-IN-17
- CAS No.: 2254432-75-0
- Formula:C21H22N4O2S
- Molecular Weight:394.49
IUPAC Name: N'-cyano-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-methylbenzenesulfonimidamide
InChIKey: SOZVZFKPLUXVMT-UHFFFAOYSA-N
SMILES: N#CN=S(NC(NC1=C(CCC2)C2=CC3=C1CCC3)=O)(C4=CC=C(C)C=C4)=O
Biological Activity: NLRP3-IN-17 is a potent, selective and orally active NLRP3 inflammasome inhibitor with an IC50 value of 7 nM. NLRP3-IN-17 significantly inhibits NLRP3 dependent IL-1β secretion in mice and can be used for chronic inflammatory diseases research[1].
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NLRP3-IN-17 | 99.02% | NLRP3-IN-17 is a potent, selective and orally active NLRP3 inflammasome inhibitor with an IC50 value of 7 nM. NLRP3-IN-17 significantly inhibits NLRP3 dependent IL-1β secretion in mice and can be used for chronic inflammatory diseases research. | ||||||||||||||||||||
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References
Keywords
