2260944-69-0
Chemical Structure
GSK702
- CAS No.: 2260944-69-0
- Formula:C45H51BrN8O7
- Molecular Weight:895.84
InChIKey: SARLMRHJAJBYBI-KZNRNLFUSA-N
SMILES: O=C(C1=CC=C([C@H]2CN(C[C@H](C2)NC(C=NN3C)=C(Br)C3=O)C)C=C1)N(C)CCCN(C)C4=CC=C(CCCOC5=C6C(C(N(C6=O)C7C(NC(CC7)=O)=O)=O)=CC=C5)C=C4
Biological Activity: GSK702, a PROTAC, is a the less active cis-(S,S)-enantiomer of GSK983 (P300/CBP-associated factor (PCAF)/general control nonderepressible 5 (GCN5) PROTAC). GSK702 induces only a small decrease of PCAF protein levels. GSK702 binds to CRBN and causes a reduction of IL-1β in macrophages. GSK702 can be used for the study of inflammatory mediators[1].
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GSK702 | GSK702, a PROTAC, is a the less active cis-(S,S)-enantiomer of GSK983 (P300/CBP-associated factor (PCAF)/general control nonderepressible 5 (GCN5) PROTAC). GSK702 induces only a small decrease of PCAF protein levels. GSK702 binds to CRBN and causes a reduction of IL-1β in macrophages. GSK702 can be used for the study of inflammatory mediators. | |||||||||||||||||||||
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Keywords
