228400-22-4
228400-22-4
Chemical Structure
AFG210
- CAS No.: 228400-22-4
- Formula:C19H14F3N3O2
- Molecular Weight:373.33
IUPAC Name: 1-(4-(pyridin-4-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea
InChIKey: DDDLGNOZDKDSEG-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(OC2=CC=NC=C2)C=C1)NC3=CC=CC(C(F)(F)F)=C3
Biological Activity: AFG210 is a potent multi-target kinase inhibitor that primarily inhibits Abl kinase (IC50=330 nM), and also has inhibitory effects on other kinases such as B-Raf, C-Raf, FGFR-1, RET and VEGF receptors. AFG210 can be used to study chronic myeloid leukemia and other diseases with abnormal activation of Abl kinase[1].
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AFG210 | AFG210 is a potent multi-target kinase inhibitor that primarily inhibits Abl kinase (IC50=330 nM), and also has inhibitory effects on other kinases such as B-Raf, C-Raf, FGFR-1, RET and VEGF receptors. AFG210 can be used to study chronic myeloid leukemia and other diseases with abnormal activation of Abl kinase. | |||||||||||||||||||||
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