2293983-99-8
Chemical Structure
JSF-3285
- CAS No.: 2293983-99-8
- Formula:C12H16FN3O2S
- Molecular Weight:285.34
InChIKey: AHVAAGWAEHSRBU-UHFFFAOYSA-N
SMILES: O=S(NC1=CC2=C(NN=C2C)C=C1)(CCCCF)=O
Biological Activity: JSF-3285 is an orally active KasA inhibitor of Mycobacterium tuberculosis (Kd = 70.7 nM). JSF-3285 inhibits KasA in the FAS-II mycolic acid biosynthesis pathway and is active against both drug-susceptible and multidrug-resistant Mycobacterium tuberculosis. JSF-3285 exhibits bactericidal efficacy in acute and chronic mouse models of tuberculosis infection. JSF-3285 significantly enhances the bactericidal and sterilizing efficacy of the Bedaquiline (HY-14881)-Pretomanid (HY-10844) combination regimen in a mouse relapse model of infection. JSF-3285 can be used for research related to tuberculosis[1][2][3].
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JSF-3285 | JSF-3285 is an orally active KasA inhibitor of Mycobacterium tuberculosis (Kd = 70.7 nM). JSF-3285 inhibits KasA in the FAS-II mycolic acid biosynthesis pathway and is active against both drug-susceptible and multidrug-resistant Mycobacterium tuberculosis. JSF-3285 exhibits bactericidal efficacy in acute and chronic mouse models of tuberculosis infection. JSF-3285 significantly enhances the bactericidal and sterilizing efficacy of the Bedaquiline (HY-14881)-Pretomanid (HY-10844) combination regimen in a mouse relapse model of infection. JSF-3285 can be used for research related to tuberculosis. | |||||||||||||||||||||
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References
- [1]. Inoyama D, et al. A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA. Cell chemical biology. 2020 May 21;27(5):560-570.e10.
- [2]. Soni H, et al. The KasA inhibitor JSF-3285 improves the sterilizing activity of bedaquiline-pretomanid-containing regimens in a mouse model of tuberculosis. Antimicrobial agents and chemotherapy. 2025 Jun 4;69(6):e00130-25.
- [3]. Soni H, et al. The KasA inhibitor JSF-3285 improves the sterilizing activity of bedaquiline-pretomanid-containing regimens in a mouse model of tuberculosis. Antimicrobial agents and chemotherapy. 2025 Jun 04;69(6):e0013025.
