2331287-27-3
Chemical Structure
11-Beta-hydroxyandrostenedione-d7
Synonym(s): 4-Androsten-11β-ol-3,17-dione-d7
- CAS No.: 2331287-27-3
- Formula:C19H19D7O3
- Molecular Weight:309.45
IUPAC Name: 2-((4-amino-5-(3,4,5-trimethoxybenzyl)-4H-1,2,4-triazol-3-yl)thio)-1-(p-tolyl)ethan-1-one
InChIKey: WSCUHXPGYUMQEX-QTKHEZQUSA-N
SMILES: C[C@@]12[C@]3([H])[C@](CC([2H])([2H])C1=C([2H])C(C([2H])([2H])C2)=O)([H])[C@@]4([H])[C@](C[C@@H]3O)(C(C([2H])([2H])C4)=O)C
Biological Activity: 11-Beta-hydroxyandrostenedione-d7 is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor[1][2]
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11-Beta-hydroxyandrostenedione-d7 | 97.0% | 11-Beta-hydroxyandrostenedione-d7 is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor | ||||||||||||||||||||
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11-Beta-hydroxyandrostenedione-d4 | 11-Beta-hydroxyandrostenedione-d4 is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. | |||||||||||||||||||||
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11-Beta-hydroxyandrostenedione | 99.97% | 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism. | ||||||||||||||||||||
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Similarity Score 0.77
HY-16875911α-Hydroxytestosterone -
Similarity Score 0.77
HY-N2337R11beta-Hydroxyprogesterone (Standard) -
Similarity Score 0.77
HY-W01124311alpha-Hydroxyprogesterone -
Similarity Score 0.76
HY-17462RAdrenosterone (Standard) -
Similarity Score 0.76
HY-N1542511β-Hydroxy-17α-methyltestosterone -
Similarity Score 0.74
HY-B1618RCorticosterone (Standard) -
Similarity Score 0.73
HY-W6999366β-Hydroxy androstenedione -
Similarity Score 0.72
HY-11461211-Ketotestosterone -
Similarity Score 0.72
HY-Z19675Testosterone impurity 1 -
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Rachelle Gent, et al. 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17αhydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol
