2410550-31-9
Chemical Structure
KVA-D-88
- CAS No.: 2410550-31-9
- Formula:C17H11Cl2F2N3O
- Molecular Weight:382.19
IUPAC Name: (1-(3,4-dichlorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)(3,3-difluoroazetidin-1-yl)methanone
InChIKey: JQEUSIGJVMRCOL-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=CC=CN=C2N1C3=CC=C(Cl)C(Cl)=C3)N4CC(F)(F)C4
Biological Activity: KVA-D-88 is a blood-brain barrier-permeable PDE4 inhibitor with IC50 values of 140 and 880 nM for PDE4B and PDE4D, respectively. KVA-D-88 induces cAMP accumulation and inhibits neuroactive substance-mediated hyperlocomotion, locomotor sensitization. KVA-D-88 can be used for the research of drug addiction[1].
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KVA-D-88 | 99.81% | KVA-D-88 is a blood-brain barrier-permeable PDE4 inhibitor with IC50 values of 140 and 880 nM for PDE4B and PDE4D, respectively. KVA-D-88 induces cAMP accumulation and inhibits neuroactive substance-mediated hyperlocomotion, locomotor sensitization. KVA-D-88 can be used for the research of drug addiction. | ||||||||||||||||||||
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Keywords
