2423992-63-4
Chemical Structure
FGFR4-IN-12
- CAS No.: 2423992-63-4
- Formula:C34H32Cl2N4O6
- Molecular Weight:663.55
IUPAC Name: N-(2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-5-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)-4-methoxyphenyl)but-2-ynamide
InChIKey: VDIDNMGZRIMBKL-PMACEKPBSA-N
SMILES: CC#CC(NC1=C(N2[C@H]3C[C@H](OC3)C2)C=C(C(C4=NC=C(C=C(C5=C(C(OC)=CC(OC)=C5Cl)Cl)C(N6CC)=O)C6=C4)=C1)OC)=O
Biological Activity: FGFR4-IN-12 (Compound A34) is a potent inhibitor of FGFR4. FGFR4-IN-12 exhibits improved FGFR4 inhibitory capability and selectivity and excellent anti-proliferative activities against FGFR4-dependent HCC cell lines. FGFR4-IN-12 has the potential for the research of cancer diseases[1]. FGFR4-IN-12 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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FGFR4-IN-12 | FGFR4-IN-12 (Compound A34) is a potent inhibitor of FGFR4. FGFR4-IN-12 exhibits improved FGFR4 inhibitory capability and selectivity and excellent anti-proliferative activities against FGFR4-dependent HCC cell lines. FGFR4-IN-12 has the potential for the research of cancer diseases. FGFR4-IN-12 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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Keywords
