2447589-08-2
2447589-08-2
Chemical Structure
COX-2-IN-22
- CAS No.: 2447589-08-2
- Formula:C29H24O7
- Molecular Weight:484.50
IUPAC Name: (E)-8-(3,5-dimethoxyphenyl)-4-(3,5-dimethoxystyryl)-2H-furo[2,3-h]chromen-2-one
InChIKey: DXJLEIVEYFLNDY-AATRIKPKSA-N
SMILES: O=C1C=C(/C=C/C2=CC(OC)=CC(OC)=C2)C3=C(C4=C(OC(C5=CC(OC)=CC(OC)=C5)=C4)C=C3)O1
Biological Activity: COX-2-IN-22 (Compound 4h) is a COX-2 inhibitor with an IC50 of 8.6 µM. COX-2-IN-22 also inhibits AChE, BChE, β-Secretase, LOX-5 and DPPH with IC50 values of 2.8, 6.3, 15.3, 13.9 and 6.8 µM, respectively. COX-2-IN-22 can cross BBB[1].
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COX-2-IN-22 | COX-2-IN-22 (Compound 4h) is a COX-2 inhibitor with an IC50 of 8.6 µM. COX-2-IN-22 also inhibits AChE, BChE, β-Secretase, LOX-5 and DPPH with IC50 values of 2.8, 6.3, 15.3, 13.9 and 6.8 µM, respectively. COX-2-IN-22 can cross BBB. | |||||||||||||||||||||
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References
Keywords
