2450279-41-9
Chemical Structure
Dual Cathepsin L/JAK-IN-1
- CAS No.: 2450279-41-9
- Formula:C19H18ClN5
- Molecular Weight:351.83
InChIKey: ZSVWQXIFVKXHGK-UHFFFAOYSA-N
SMILES: CN1C=C(C2=CC=CC=C21)C3=CC=NC(NC4=CC=CC(N)=C4)=N3.Cl
Biological Activity: Dual Cathepsin L/JAK-IN-1 (Compound A8) is a dual inhibitor of Cathepsin L (CTSL) and JAK, with IC50 values of 0.68 μM, 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for CTSL, JAK1/2/3, and TYK2, respectively. Dual Cathepsin L/JAK-IN-1 effectively blocks the activation of the MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. Dual Cathepsin L/JAK-IN-1 can be used in research on acute lung injury (ALI)[1].
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Dual Cathepsin L/JAK-IN-1 | 98.47% | Dual Cathepsin L/JAK-IN-1 (Compound A8) is a dual inhibitor of Cathepsin L (CTSL) and JAK, with IC50 values of 0.68 μM, 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for CTSL, JAK1/2/3, and TYK2, respectively. Dual Cathepsin L/JAK-IN-1 effectively blocks the activation of the MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. Dual Cathepsin L/JAK-IN-1 can be used in research on acute lung injury (ALI). | ||||||||||||||||||||
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Keywords
