256382-08-8
Chemical Structure
Rivenprost
Synonym(s): ONO-4819; ONO-AE1-734
- CAS No.: 256382-08-8
- Formula:C24H34O6S
- Molecular Weight:450.59
IUPAC Name: methyl 4-((2-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxy-4-(3-(methoxymethyl)phenyl)but-1-en-1-yl)-5-oxocyclopentyl)ethyl)thio)butanoate
InChIKey: FBQUXLIJKPWCAO-AZIFJQEOSA-N
SMILES: COCC1=CC=CC(C[C@H](O)/C=C/[C@@H]2[C@H](C(C[C@H]2O)=O)CCSCCCC(OC)=O)=C1
Biological Activity:
Rivenprost (ONO-4819; ONO-AE1-734) is a selective agonist for prostaglandin E receptor EP4 with Ki of 0.7 nM. Rivenprost exhibits hepatoprotective and bone anabolic effects[1][2].
The product specifications provided below refer solely to the active content of Rivenprost.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Rivenprost | 99.0% | Rivenprost (ONO-4819; ONO-AE1-734) is a selective agonist for prostaglandin E receptor EP4 with Ki of 0.7 nM. Rivenprost exhibits hepatoprotective and bone anabolic effects. The product specifications provided below refer solely to the active content of Rivenprost. |
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Similarity Score 0.60
HY-12803917-Phenyl-ω-trinor-PGE2 -
Similarity Score 0.59
HY-13886817-Phenyl trinor prostaglandin E2 ethyl amide -
Similarity Score 0.56
HY-1597049-Keto-latanoprost -
Similarity Score 0.55
HY-B0191BBimatoprost methyl ester -
Similarity Score 0.55
HY-14958817-Trifluoromethylphenyl trinor prostaglandin F2α methyl ester -
Similarity Score 0.55
HY-129920Prostaglandin E2 methyl ester -
Similarity Score 0.54
HY-13728817-Phenyl-18,19,20-trinor-PGD2 -
Similarity Score 0.54
HY-106074Mexiprostil -
Similarity Score 0.54
HY-13754416-Phenyl tetranor Prostaglandin F2α -
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References
- [1]. Ninomiya T, et al., Prostaglandin E(2) receptor EP(4)-selective agonist (ONO-4819) increases bone formation by modulating mesenchymal cell differentiation. Eur J Pharmacol. 2011 Jan 10;650(1):396-402. [Content Brief]
- [2]. Kasai K, et al., A novel prostaglandin E receptor subtype agonist, 0N0-4819, attenuates acute experimental liver injury in rats. Hepatol Res. 2001 Nov;21(3):252-260. [Content Brief]
