2565637-94-5
2565637-94-5
Chemical Structure
AB25583
- CAS 番号: 2565637-94-5
- Formula:C22H17ClN4O3S
- Molecular Weight:452.91
InChIKey: NKBJFGOHTSTLNB-UHFFFAOYSA-N
SMILES: ClC1=CC=C(COC2=NN=C(NC(C3=C(C4=CC=CC=C4OC)C=CN=C3)=O)S2)C=C1
Biological Activity:
AB25583 is a Polθ helicase (Polθ-hel) small molecule inhibitor, with an IC50 value of 6 nM. AB25583 selectively kills BRCA1/2 deficient cells and works in synergy with Olaparib (HY-10162) in cancer cells carrying pathogenic BRCA1/2 mutations. AB25583 can be used for tumor research[1].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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AB25583 | 99.87% | AB25583 is a Polθ helicase (Polθ-hel) small molecule inhibitor, with an IC50 value of 6 nM. AB25583 selectively kills BRCA1/2 deficient cells and works in synergy with Olaparib (HY-10162) in cancer cells carrying pathogenic BRCA1/2 mutations. AB25583 can be used for tumor research. |
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Structural Analogs
-
Similarity Score 0.74
HY-150279PolQi2 -
Similarity Score 0.53
HY-169285Polθ-IN-6 -
Similarity Score 0.49
HY-161302Polθ/PARP-IN-1 -
Similarity Score 0.49
HY-169858Prostaglandin E2 Inhibitor 3 -
Similarity Score 0.49
HY-13237GSK2578215A -
Similarity Score 0.48
HY-118387AVE-0118 -
Similarity Score 0.48
HY-177273Kinase modulator-1 -
Similarity Score 0.48
HY-12083PPY-A -
Similarity Score 0.48
HY-49458WAY-232897 -
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