268739-54-4
Chemical Structure
(R)-Monastrol
Synonym(s): (-)-Monastrol
- CAS No.: 268739-54-4
- Formula:C14H16N2O3S
- Molecular Weight:292.35
InChIKey: LOBCDGHHHHGHFA-GFCCVEGCSA-N
SMILES: O=C(OCC)C1=C(NC(N[C@@H]1C2=CC=CC(O)=C2)=S)C
Biological Activity: (R)-Monastrol ((-)-Monastrol) is the enantiomer of Monastrol (HY-101071A) and an allosteric inhibitor of the mitotic kinesin Eg5. (R)-Monastrol promotes the folding of the L5 domain and the docking of the neck linker, and inhibits the ATPase activity of the Eg5 motor domain as well as microtubule-stimulated ATPase activity. (R)-Monastrol induces monopolar spindle formation. (R)-Monastrol can be used in research related to Eg5-mediated diseases, such as cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(R)-Monastrol | 98.19% | (R)-Monastrol ((-)-Monastrol) is the enantiomer of Monastrol (HY-101071A) and an allosteric inhibitor of the mitotic kinesin Eg5. (R)-Monastrol promotes the folding of the L5 domain and the docking of the neck linker, and inhibits the ATPase activity of the Eg5 motor domain as well as microtubule-stimulated ATPase activity. (R)-Monastrol induces monopolar spindle formation. (R)-Monastrol can be used in research related to Eg5-mediated diseases, such as cancer. | ||||||||||||||||||||
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References
- [1]. Maliga Z, et al. Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5. Chemistry & biology. 2002 Sep;9(9):989-96.
- [2]. Maliga Z, et al. A pathway of structural changes produced by monastrol binding to Eg5. The Journal of biological chemistry. 2006 Mar 24;281(12):7977-82.
