(R)-Monastrol
Based on 1 Customer Validation
(R)-Monastrol ((-)-Monastrol) is the enantiomer of Monastrol (HY-101071A) and an allosteric inhibitor of the mitotic kinesin Eg5. (R)-Monastrol promotes the folding of the L5 domain and the docking of the neck linker, and inhibits the ATPase activity of the Eg5 motor domain as well as microtubule-stimulated ATPase activity. (R)-Monastrol induces monopolar spindle formation. (R)-Monastrol can be used in research related to Eg5-mediated diseases, such as cancer.
For research use only. We do not sell to patients.
- Purity : 98.19%
- CAS No.: 268739-54-4
- Formula: C14H16N2O3S
- Molecular Weight:292.35
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Kinesin Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
Eg5 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 268739-54-4
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Appearance Solid
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Molecular Weight 292.35
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Formula C14H16N2O3S
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Color White to off-white
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SMILES
O=C(OCC)C1=C(NC(N[C@@H]1C2=CC=CC(O)=C2)=S)C
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Synonyms
(-)-Monastrol
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (342.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (287 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.4206 mL | 17.1028 mL | 34.2056 mL | 85.5139 mL |
| 5 mM | 0.6841 mL | 3.4206 mL | 6.8411 mL | 17.1028 mL | |
| 10 mM | 0.3421 mL | 1.7103 mL | 3.4206 mL | 8.5514 mL | |
| 15 mM | 0.2280 mL | 1.1402 mL | 2.2804 mL | 5.7009 mL | |
| 20 mM | 0.1710 mL | 0.8551 mL | 1.7103 mL | 4.2757 mL | |
| 25 mM | 0.1368 mL | 0.6841 mL | 1.3682 mL | 3.4206 mL | |
| 30 mM | 0.1140 mL | 0.5701 mL | 1.1402 mL | 2.8505 mL | |
| 40 mM | 0.0855 mL | 0.4276 mL | 0.8551 mL | 2.1378 mL | |
| 50 mM | 0.0684 mL | 0.3421 mL | 0.6841 mL | 1.7103 mL | |
| 60 mM | 0.0570 mL | 0.2850 mL | 0.5701 mL | 1.4252 mL | |
| 80 mM | 0.0428 mL | 0.2138 mL | 0.4276 mL | 1.0689 mL | |
| 100 mM | 0.0342 mL | 0.1710 mL | 0.3421 mL | 0.8551 mL |
(R)-Monastrol Related Classifications
HY-101071B Related Classifications
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