2701435-64-3
2701435-64-3
Chemical Structure
(Rac)-SCH 563705
- CAS No.: 2701435-64-3
- Formula:C23H27N3O5
- Molecular Weight:425.48
InChIKey: DGKQQEVYYPCMNE-UHFFFAOYSA-N
SMILES: O=C(C(NC1=CC=CC(C(N(C)C)=O)=C1O)=C2NC(CC)C3=CC(C(C)C)=CO3)C2=O
Biological Activity: (Rac)-SCH 563705 is a racemic mixture of SCH 563705 (HY-10011). SCH 563705 (compound 16) is a potent and orally active CXCR2 and CXCR1 antagonist with IC50 values of 1.3 nM and 7.3 nM and Ki values of 1 nM and 3 nM, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(Rac)-SCH 563705 | 99.78% | (Rac)-SCH 563705 is a racemic mixture of SCH 563705 (HY-10011). SCH 563705 (compound 16) is a potent and orally active CXCR2 and CXCR1 antagonist with IC50 values of 1.3 nM and 7.3 nM and Ki values of 1 nM and 3 nM, respectively. | ||||||||||||||||||||
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(Rac)-SCH 563705 (Standard) | ≥98% | (Rac)-SCH 563705 (Standard) is the analytical standard of (Rac)-SCH 563705 (HY-10011B). This product is intended for research and analytical applications. (Rac)-SCH 563705 is a racemic mixture of SCH 563705 (HY-10011). SCH 563705 (compound 16) is a potent and orally active CXCR2 and CXCR1 antagonist with IC50 values of 1.3 nM and 7.3 nM and Ki values of 1 nM and 3 nM, respectively. | ||||||||||||||||||||
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References
- [1]. Min S H, et al. Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis[J]. Biochemical and biophysical research communications, 2010, 391(1): 1080-1086. [Content Brief]
- [2]. Chao J, et al. C (4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists[J]. Bioorganic & medicinal chemistry letters, 2007, 17(13): 3778-3783. [Content Brief]
