2748800-07-7
Chemical Structure
(2S,3R,4S)-ASX-173
- CAS No.: 2748800-07-7
- Formula:C28H30FN3O3
- Molecular Weight:475.55
InChIKey: CRICQRYLVUOXCF-MFYWSIJSSA-N
SMILES: CC[C@@H](C(N1C[C@H](C2=CC=C(C=C2)F)[C@@H](O)[C@H]1C(NC(C3=CC=CC=C3)C4=CC=CC=C4)=O)=O)N
Biological Activity: (2S,3R,4S)-ASX-173 is the (2S,3R,4S)-enantiomer of ASX-173 (HY-175282). ASX-173 is an orally active inhibitor of asparagine synthetase (ASNS) (IC50 = 0.113 μM, Ki = 0.4 nM). ASX-173 enhances the anticancer activity of L-asparaginase (ASNase) (HY-P1923). ASX-173 disrupts nucleotide synthesis and induces leukemia cell cycle arrest, apoptosis and autophagy in leukemia cells in combination with ASNase. ASX-173 slows the growth of OCI-AML2 xenografts in combination with ASNase. ASX-173 is indicated for the study of acute lymphoblastic leukemia, acute myeloid leukemia, colorectal cancer, and other cancers[1].
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(2S,3R,4S)-ASX-173 | 99.29% | (2S,3R,4S)-ASX-173 is the (2S,3R,4S)-enantiomer of ASX-173 (HY-175282). ASX-173 is an orally active inhibitor of asparagine synthetase (ASNS) (IC50 = 0.113 μM, Ki = 0.4 nM). ASX-173 enhances the anticancer activity of L-asparaginase (ASNase) (HY-P1923). ASX-173 disrupts nucleotide synthesis and induces leukemia cell cycle arrest, apoptosis and autophagy in leukemia cells in combination with ASNase. ASX-173 slows the growth of OCI-AML2 xenografts in combination with ASNase. ASX-173 is indicated for the study of acute lymphoblastic leukemia, acute myeloid leukemia, colorectal cancer, and other cancers. | ||||||||||||||||||||
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Keywords
