2764774-91-4
2764774-91-4
Chemical Structure
Sigvotatug vedotin
Synonym(s): SGN-B6A; PF-08046047
- CAS No.: 2764774-91-4
- Molecular Weight:150000 (average)
SMILES: [Sigvotatug vedotin]
Biological Activity: Sigvotatug vedotin (SGN-B6A; PF-08046047) is an ADC that targets integrin β-6 (ITGB6) via the human IgG1 monoclonal antibody Sigvotatug (HY-P990764) (EC50 = 0.9 nM) and exhibits cytotoxicity against a variety of integrin β-6-positive cancer cells through the tubulin polymerization inhibitor MMAE (HY-15162)[1].
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Sigvotatug vedotin | 98.42% | Sigvotatug vedotin (SGN-B6A; PF-08046047) is an ADC that targets integrin β-6 (ITGB6) via the human IgG1 monoclonal antibody Sigvotatug (HY-P990764) (EC50 = 0.9 nM) and exhibits cytotoxicity against a variety of integrin β-6-positive cancer cells through the tubulin polymerization inhibitor MMAE (HY-15162). | ||||||||||||||||||||
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