2784577-71-3
Chemical Structure
RLX-33
- CAS No.: 2784577-71-3
- Formula:C24H19ClN4O4
- Molecular Weight:462.89
IUPAC Name: 4-cyclopropylpyrimidin-5-amine
InChIKey: LTOAWFRZXVPHAJ-UHFFFAOYSA-N
SMILES: O=C(C(C1)CN(CC2=CC=CO2)C1=O)NC3=CC=C(C4=NC(C5=CC=C(Cl)C=C5)=NO4)C=C3
Biological Activity: RLX-33 is a potent, selective and blood-brain barrier (BBB) penetrant relaxin family peptide 3 (RXFP3) antagonist, also blocks relaxin-3-induced ERK1/2 phosphorylation, with IC50 values of 2.36 μM for RXFP3, 7.82 and 13.86 μM for ERK1 and ERK2 phosphorylation, respectively. RLX-33 can block the stimulation of food intake induced by the RXFP3-selective agonist R3/I5 in rats. RLX-33 can be used for the research of metabolic syndrome[1].
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RLX-33 | 99.79% | RLX-33 is a potent, selective and blood-brain barrier (BBB) penetrant relaxin family peptide 3 (RXFP3) antagonist, also blocks relaxin-3-induced ERK1/2 phosphorylation, with IC50 values of 2.36 μM for RXFP3, 7.82 and 13.86 μM for ERK1 and ERK2 phosphorylation, respectively. RLX-33 can block the stimulation of food intake induced by the RXFP3-selective agonist R3/I5 in rats. RLX-33 can be used for the research of metabolic syndrome. | ||||||||||||||||||||
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