2796292-75-4
Chemical Structure
Keap1-Nrf2-IN-11
- CAS. Nr.: 2796292-75-4
- Formula:C36H43N7O8S2
- Molecular Weight:765.90
IUPAC Name: N-(4-(N-(2-amino-2-oxoethyl)-N-(4-((N-(2-amino-2-oxoethyl)-4-methoxyphenyl)sulfonamido)naphthalen-1-yl)sulfamoyl)phenyl)-3-(4-ethylpiperazin-1-yl)propanamide
InChIKey: ZELGLHRMBBOISG-UHFFFAOYSA-N
SMILES: O=S(N(C1=C2C(C=CC=C2)=C(C=C1)N(S(=O)(C3=CC=C(C=C3)NC(CCN4CCN(CC4)CC)=O)=O)CC(N)=O)CC(N)=O)(C5=CC=C(C=C5)OC)=O
Biological Activity: Keap1-Nrf2-IN-11 (compound 6k) is a Keap1-Nrf2 inhibitor with KD2 value of 0.21 nM. Keap1-Nrf2-IN-11 inhibits the productions of ROS and NO and the expression of TNF-α. Keap1-Nrf2-IN-11 relieves inflammations by increasing the Nrf2 nuclear translocation. Keap1-Nrf2-IN-11 can be used for anti-inflammatory research[1].
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Keap1-Nrf2-IN-11 | Keap1-Nrf2-IN-11 (compound 6k) is a Keap1-Nrf2 inhibitor with KD2 value of 0.21 nM. Keap1-Nrf2-IN-11 inhibits the productions of ROS and NO and the expression of TNF-α. Keap1-Nrf2-IN-11 relieves inflammations by increasing the Nrf2 nuclear translocation. Keap1-Nrf2-IN-11 can be used for anti-inflammatory research. | |||||||||||||||||||||
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