2803307-04-0
2803307-04-0
Chemical Structure
PT-88
- CAS No.: 2803307-04-0
- Formula:C30H31N7O5
- Molecular Weight:569.61
InChIKey: AVZAKRMYVPBYAL-KFGJODCASA-N
SMILES: O=C(NC1=CC=C(C2=NC(N3C4COCC3CC4)=NC(N5[C@@H]6COC[C@H]5CC6)=N2)C=C1)NC7=CC8=C(C=C7)C(OC8)=O
Biological Activity: PT-88 is a potent and selective ATP-competitive mTOR kinase inhibitor, IC50 = 1.2 nM. PT-88 inhibits both mTORC1 and mTORC2 and blocks the phosphorylation of their downstream proteins (such as p70S6K, 4EBP1, and Akt), thereby inducing cancer cell cycle arrest, autophagy, and apoptosis. PT-88 can be used for research on human breast cancer[1].
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PT-88 | PT-88 is a potent and selective ATP-competitive mTOR kinase inhibitor, IC50 = 1.2 nM. PT-88 inhibits both mTORC1 and mTORC2 and blocks the phosphorylation of their downstream proteins (such as p70S6K, 4EBP1, and Akt), thereby inducing cancer cell cycle arrest, autophagy, and apoptosis. PT-88 can be used for research on human breast cancer. | |||||||||||||||||||||
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