2810747-89-6
2810747-89-6
Chemical Structure
BLU2864
- CAS No.: 2810747-89-6
- Formula:C24H19F3N4O2
- Molecular Weight:452.43
IUPAC Name: N-((1R,2S)-5-(difluoromethyl)-7-fluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-6-(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)nicotinamide
InChIKey: VRPOVDLLZCQZEG-RXVVDRJESA-N
SMILES: FC1=CC(C(F)F)=CC2=C1[C@H]([C@@H](O)C2)NC(C(C=C3)=CN=C3C4=C(C(C)=CN5)C5=NC=C4)=O
Biological Activity: BLU2864 is an orally active, highly selective, ATP-competitive PRKACA inhibitor (IC50=0.3 nM). BLU2864 shows anti-tumor activity. BLU2864 can be used in cancer and polycystic kidney disease research[1][2].
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BLU2864 | 99.50% | BLU2864 is an orally active, highly selective, ATP-competitive PRKACA inhibitor (IC50=0.3 nM). BLU2864 shows anti-tumor activity. BLU2864 can be used in cancer and polycystic kidney disease research. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.54
HY-153967BLU0588 -
Similarity Score 0.46
HY-117408VU6004256 -
Similarity Score 0.46
HY-130255BTK inhibitor 13 -
Similarity Score 0.46
HY-122163MK-3901 -
Similarity Score 0.45
HY-150752BTK-IN-15 -
Similarity Score 0.45
HY-116480LY593093 -
Similarity Score 0.45
HY-149262CLK1-IN-3 -
Similarity Score 0.45
HY-111472Porcn-IN-1 -
Similarity Score 0.45
HY-12964SGI-7079 -
Explore the MedChemAI to find more analogs
References
- [1]. Xiaofang Wang, et al. Protein Kinase A Downregulation Delays the Development and Progression of Polycystic Kidney Disease. J Am Soc Nephrol. 2022 Jun;33(6):1087-1104. [Content Brief]
- [2]. Stefanie S. Schalm, et al. Evaluation of PRKACA as a Therapeutic Target for Fibrolamellar Carcinoma. bioRxiv 2022.01.31.477690.
