2816095-52-8
Chemical Structure
Tat-βsyn-degron
- CAS No.: 2816095-52-8
- Formula:C132H237N59O31
- Molecular Weight:3146.67
SMILES: OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC(CNC([C@H](CO)NC([C@H](CCCCN)NC([C@H]([C@H](O)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC(CNC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(O)=O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O
Biological Activity: Tat-βsyn-degron is a Degron peptide that can cross the blood-brain barrier. Tat-βsyn-degron binds to α-synuclein through a β-synuclein-derived domain, promotes proteasomal degradation, and can induce the release of lactate dehydrogenase from primary cortical neurons. Tat-βsyn-degron can be used in research on Parkinson's disease[1][2].
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Tat-βsyn-degron | Tat-βsyn-degron is a Degron peptide that can cross the blood-brain barrier. Tat-βsyn-degron binds to α-synuclein through a β-synuclein-derived domain, promotes proteasomal degradation, and can induce the release of lactate dehydrogenase from primary cortical neurons. Tat-βsyn-degron can be used in research on Parkinson's disease. | |||||||||||||||||||||
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References
- [1]. Jin JW, et al. Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models. Communications biology. 2021 Feb 19;4(1):232. [Content Brief]
- [2]. Nishanth DS, et al. Molecular Mechanisms and Therapeutic Potential of Degron-Mediated Proteostasis Regulation in Neurodegenerative Diseases. Cellular and molecular neurobiology. 2026 Jan 13;46(1):26.
