2820126-32-5
Chemical Structure
EGFR/HER2-IN-8
- CAS No.: 2820126-32-5
- Formula:C16H16N4O2S
- Molecular Weight:328.39
IUPAC Name: N'-propionyl-5-(p-tolyl)imidazo[2,1-b]thiazole-3-carbohydrazide
InChIKey: VNEUERRAUAGHGO-UHFFFAOYSA-N
SMILES: O=C(C1=CSC2=NC=C(C3=CC=C(C)C=C3)N21)NNC(CC)=O
Biological Activity: EGFR/HER2-IN-8 (compound 34) is a EGFR/HER2 and DHFR inhibitor. EGFR/HER2-IN-8 inhibits EGFR kinase, HER2 kinase and DHFR with IC50s of 0.45, 0.244 and 5.669 μM, respectively. EGFR/HER2-IN-8 shows anticancer activity against several cancer cell lines with high safety profile and selectivity indices. EGFR/HER2-IN-8 can be used for the research of cancer[1].
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EGFR/HER2-IN-8 | EGFR/HER2-IN-8 (compound 34) is a EGFR/HER2 and DHFR inhibitor. EGFR/HER2-IN-8 inhibits EGFR kinase, HER2 kinase and DHFR with IC50s of 0.45, 0.244 and 5.669 μM, respectively. EGFR/HER2-IN-8 shows anticancer activity against several cancer cell lines with high safety profile and selectivity indices. EGFR/HER2-IN-8 can be used for the research of cancer. | |||||||||||||||||||||
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Keywords
