2851905-89-8
Chemical Structure
JEDI-1444
- CAS No.: 2851905-89-8
- Formula:C26H27F3N4O5S2
- Molecular Weight:596.64
InChIKey: JURGWQSEARSCQN-UHFFFAOYSA-N
SMILES: O=C(C1=C(N(S(=O)(C)=O)C)C=CC=C1)NC2=CC=C(S(=O)(N3CCN(CC3)C4=CC=CC(C(F)(F)F)=C4)=O)C=C2
Biological Activity: JEDI-1444 is an LpxH inhibitor and the common core scaffold of EBL‑3599 (HY-187937) and EBL‑3647 (HY-187938). JEDI-1444 inhibits a manganese-dependent phosphatase, blocking the biosynthesis of lipid A and lipopolysaccharide in Gram-negative bacteria. JEDI-1444 exhibits antibacterial activity against Escherichia coli and is active against wild-type Escherichia coli and Klebsiella pneumoniae possessing efflux function. JEDI-1444 can be used in research related to bacterial infections and peritonitis[1][2][3].
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JEDI-1444 | JEDI-1444 is an LpxH inhibitor and the common core scaffold of EBL‑3599 (HY-187937) and EBL‑3647 (HY-187938). JEDI-1444 inhibits a manganese-dependent phosphatase, blocking the biosynthesis of lipid A and lipopolysaccharide in Gram-negative bacteria. JEDI-1444 exhibits antibacterial activity against Escherichia coli and is active against wild-type Escherichia coli and Klebsiella pneumoniae possessing efflux function. JEDI-1444 can be used in research related to bacterial infections and peritonitis. | |||||||||||||||||||||
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References
- [1]. Zhang G, et al. Structure-Based Discovery of a New LpxH-Targeted Chemotype with Activity against Klebsiella pneumoniae. Journal of Medicinal Chemistry. 2026 Mar 26;69(6):6691-705. [Content Brief]
- [2]. Dome PA, et al. From Obscurity to Opportunity: LpxH Emerges as a Promising Antibiotic Target in the Battle against Gram-Negative Pathogens. ACS infectious diseases. 2025 Nov 14;11(11):2993-3008.
- [3]. Huseby DL, et al. Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria. Proceedings of the National Academy of Sciences of the United States of America. 2024 Apr 09;121(15):e2317274121.
