JEDI-1444
JEDI-1444 is an LpxH inhibitor and the common core scaffold of EBL‑3599 (HY-187937) and EBL‑3647 (HY-187938). JEDI-1444 inhibits a manganese-dependent phosphatase, blocking the biosynthesis of lipid A and lipopolysaccharide in Gram-negative bacteria. JEDI-1444 exhibits antibacterial activity against Escherichia coli and is active against wild-type Escherichia coli and Klebsiella pneumoniae possessing efflux function. JEDI-1444 can be used in research related to bacterial infections and peritonitis.
For research use only. We do not sell to patients.
- CAS No.: 2851905-89-8
- Formula: C26H27F3N4O5S2
- Molecular Weight:596.64
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
JEDI-1444 inhibits E. coli LpxH with an IC50 of 2.6 nM; it is active against wild-type E. coli ATCC 25922 and K. pneumoniae ATCC 13883 with an MIC of 2 mg/L, shows stronger activity against ΔtolC E. coli (≤0.125 mg/L), and exhibits reduced activity in 50% human serum (32 mg/L)[3].
JEDI-1444 selects resistant E. coli at a low frequency, with mutations restricted to LpxH[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2851905-89-8
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Molecular Weight 596.64
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Formula C26H27F3N4O5S2
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SMILES
O=C(C1=C(N(S(=O)(C)=O)C)C=CC=C1)NC2=CC=C(S(=O)(N3CCN(CC3)C4=CC=CC(C(F)(F)F)=C4)=O)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JEDI-1444 Related Classifications
HY-187940 Related Classifications
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Keywords
- JEDI-1444
- 2851905-89-8
- JEDI1444
- JEDI 1444
- Bacterial
- Drug Intermediate
- Drug Iintermediate
- Escherichia coli
- Gram-negative bacteria
- Klebsiella pneumoniae
- LpxH
- antibacterial
- efflux
- gram-negative bacterial infections
- lipid A biosynthesis
- lipopolysaccharide biosynthesis
- manganese-dependent phosphoesterase
- Inhibitor
- inhibitor
- inhibit