2868357-11-1
Chemical Structure
Glucocorticoid receptor modulator 1
- CAS No.: 2868357-11-1
- Formula:C24H23ClN2O4S
- Molecular Weight:470.97
IUPAC Name: N-(1-benzoyl-1,2,3,4-tetrahydroquinolin-6-yl)-5-chloro-2-methoxy-4-methylbenzenesulfonamide
InChIKey: BDARZHMPJRWQLB-UHFFFAOYSA-N
SMILES: COC1=C(C=C(C(C)=C1)Cl)S(=O)(NC2=CC=C3C(CCCN3C(C4=CC=CC=C4)=O)=C2)=O
Biological Activity: Glucocorticoid receptor modulator 1 is a highly potent and orally active non-steroidal selective glucocorticoid receptor modulator with an IC50 value of 9 nM and 130 nM for NF-κB and AP-1, respectively. Glucocorticoid receptor modulator 1 can effectively reduce the expression of inflammatory factors IL-6, IL-1β, TNF-α, also can relieve dermatitis in mice[1].
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Glucocorticoid receptor modulator 1 | 99.79% | Glucocorticoid receptor modulator 1 is a highly potent and orally active non-steroidal selective glucocorticoid receptor modulator with an IC50 value of 9 nM and 130 nM for NF-κB and AP-1, respectively. Glucocorticoid receptor modulator 1 can effectively reduce the expression of inflammatory factors IL-6, IL-1β, TNF-α, also can relieve dermatitis in mice. | ||||||||||||||||||||
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Keywords
