2882-15-7
2882-15-7
Chemical Structure
N-Deschlorobenzoyl indomethacin
- CAS No.: 2882-15-7
- Formula:C12H13NO3
- Molecular Weight:219.24
IUPAC Name: 5-Methoxy-2-methyl-3-indoleacetic acid
InChIKey: TXWGINUZLBAKDF-UHFFFAOYSA-N
SMILES: CC(N1)=C(C2=C1C=CC(OC)=C2)CC(O)=O
Biological Activity: N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin (HY-14397), lacks the N-p-chlorobenzoyl group in its structure. Consequently, N-Deschlorobenzoyl indomethacin loses inhibitory activity against AKR1C2 and AKR1C3 (AKR1C2 IC50 =100 μM, AKR1C3 IC50 >100 μM), exhibiting no selectivity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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N-Deschlorobenzoyl indomethacin | 95.0% | N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin (HY-14397), lacks the N-p-chlorobenzoyl group in its structure. Consequently, N-Deschlorobenzoyl indomethacin loses inhibitory activity against AKR1C2 and AKR1C3 (AKR1C2 IC50 =100 μM, AKR1C3 IC50 >100 μM), exhibiting no selectivity. | ||||||||||||||||||||
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N-Deschlorobenzoyl indomethacin-d3 | N-Deschlorobenzoyl indomethacin-d3 is the deuterium labeled N-Deschlorobenzoyl indomethacin (HY-W008567). N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin (HY-14397), lacks the N-p-chlorobenzoyl group in its structure. Consequently, N-Deschlorobenzoyl indomethacin loses inhibitory activity against AKR1C2 and AKR1C3 (AKR1C2 IC50 =100 μM, AKR1C3 IC50 >100 μM), exhibiting no selectivity. | |||||||||||||||||||||
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References
