2886772-68-3
2886772-68-3
Chemical Structure
GL0388
- CAS No.: 2886772-68-3
- Formula:C21H17FN2O
- Molecular Weight:332.37
IUPAC Name: (E)-2-((3-((2-fluoro-9H-fluoren-9-ylidene)methyl)pyridin-2-yl)oxy)ethan-1-amine
InChIKey: WCVGRSPKTHQNCR-XDHOZWIPSA-N
SMILES: NCCOC1=NC=CC=C1/C=C2C3=C(C4=C\2C=C(C=C4)F)C=CC=C3
Biological Activity: GL0388 is a Bax activator that results in Bax insertion into mitochondrial membrane. GL0388 shows antiproliferative activities against various cancer cells, with IC50s of 0.299-1.57 μM. GL0388 activates Bax and induce Bax-mediated apoptosis. GL0388 suppresses breast cancer xenograft tumor growth in vivo[1].
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GL0388 | 99.22% | GL0388 is a Bax activator that results in Bax insertion into mitochondrial membrane. GL0388 shows antiproliferative activities against various cancer cells, with IC50s of 0.299-1.57 μM. GL0388 activates Bax and induce Bax-mediated apoptosis. GL0388 suppresses breast cancer xenograft tumor growth in vivo. | ||||||||||||||||||||
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