2. Apoptosis
  3. Bcl-2 Family Apoptosis
  4. CYD-4-61

CYD-4-61 is a novel Bax activator used for breast cancer research. CYD-4-61 inhibits triple-negative breast cancer MDA-MB-231 and ER-positive breast cancer MCF-7 cell lines proliferation. CYD-4-61 activates Bax protein to induce cytochrome c release and regulate apoptotic biomarkers, leading to cancer cell apoptosis.

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CYD-4-61 Chemical Structure

CYD-4-61 Chemical Structure

CAS No. : 1425944-33-7

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CYD-4-61 Related Antibodies

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Description

CYD-4-61 is a novel Bax activator used for breast cancer research. CYD-4-61 inhibits triple-negative breast cancer MDA-MB-231 and ER-positive breast cancer MCF-7 cell lines proliferation. CYD-4-61 activates Bax protein to induce cytochrome c release and regulate apoptotic biomarkers, leading to cancer cell apoptosis[1].

IC50 & Target[1]

Bax

 

In Vitro

CYD-4-61 (compound 49) (0-10 μM; 72 h) exhibits significantly improved antiproliferative activity with IC50s of 0.07 µM against triple-negative breast cancer MDA-MB-231 and 0.06 µM against ER-positive breast cancer MCF-7 cell lines, respectively[1].
CYD-4-61 (1 μM; 72 h) induces apoptosis among MCF-7 and MDA-MB-231 cells[1].
CYD-4-61 (5 μM and 10 μM; ) increases the level of cells with apoptotic bodies in MDA-MB-231 and MCF-7 cells[1].
CYD-4-61 (5 μM; 0-48 h) decreases the level of p-Bax, but increases the levle of total Bax protein, cytochrome c, and several protein markers related to apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CYD-4-61 Related Antibodies

Cell Viability Assay[1]

Cell Line: MCF-10A, T47D, MCF-7, MDA-MB-231, and MDA-MB-468 cells
Concentration: 0.1, 1, and 10 μM
Incubation Time: 72 hours
Result: Inhibited triple-negative breast cancer MDA-MB-231 and ER-positive breast cancer MCF-7 cell lines proliferation and viability.

Western Blot Analysis[1]

Cell Line: MCF-7 and MDA-MB-231 cells
Concentration: 5 μM
Incubation Time: 0, 6, 12, 24, and 48 hours
Result: Dose-dependently led to the upregulation of cleaved PARP-1, cleaved caspase 3, and downregulation of cyclin D1.
In Vivo

CYD-4-61 (2.5 mg/kg; i.p.; once daily for 7 d) inhibits triple-negative breast tumor growth in xenograft model in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Triple-negative breast cancer MDA-MB-231 xenograft model in mice[1]
Dosage: 2.5 mg/kg
Administration: Intraperitoneal injection; once daily for 7 consecutive days
Result: Significantly suppressed the growth of MDA-MB-231 tumors with an inhibition rate of 55%.
Molecular Weight

359.38

Formula

C21H17N3O3
CAS No.
SMILES

NCCOC1=NC=CC=C1/C=C2C3=C(C4=C/2C=CC=C4)C=CC([N+]([O-])=O)=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CYD-4-61 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYD-4-611425944-33-7Bcl-2 FamilyApoptosistriple-negative breast cancer MDA-MB-231ER-positive breast cancer MCF-7 cellcytochrome cInhibitorinhibitorinhibit

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