2891469-99-9
2891469-99-9
Chemical Structure
JAK-IN-30
- CAS No.: 2891469-99-9
- Formula:C19H26N8S
- Molecular Weight:398.53
InChIKey: VGBYAYCYPVFDTM-UHFFFAOYSA-N
SMILES: N#CCC1(N2CCN(CC2)C)CN(C1)C(N=C3NC4=CC(C)=NS4)=C(C=N3)C
Biological Activity: JAK-IN-30 (compound 31) is a water-soluble JAK inhibitor with IC50 values of 2, 15, 18 and 2 nM for JAK2, JAK1, JAK3 and TYK2, respectively. JAK-IN-30 has research potential for dry eye disease (DED)[1].
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JAK-IN-30 | JAK-IN-30 (compound 31) is a water-soluble JAK inhibitor with IC50 values of 2, 15, 18 and 2 nM for JAK2, JAK1, JAK3 and TYK2, respectively. JAK-IN-30 has research potential for dry eye disease (DED). | |||||||||||||||||||||
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References
- [1]. Gordhan HM, et al. Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility. J Med Chem. 2023 Jul 13;66(13):8929-8950. [Content Brief]
