2902706-25-4
Chemical Structure
CN016
- CAS No.: 2902706-25-4
- Formula:C21H36N9O5P
- Molecular Weight:525.54
InChIKey: YNGSKNHAZWDVCI-UHFFFAOYSA-N
SMILES: OCCCN1N=NC(CNC2=NC(N3CCOCC3)=CC(NC4CCN(CC4)CCP(O)(O)=O)=N2)=C1
Biological Activity: CN016 is a neuroprotective agent. CN016 inhibits the elevation of pro-inflammatory cytokines G-CSF, GM-CSF and IL-6 induced by Oxaliplatin (HY-17371). CN016 suppresses Paclitaxel (HY-B0015)-induced inflammatory responses and immune cell infiltration into sensory neurons. CN016 protects neurons from Paclitaxel (HY-B0015)-induced neurotoxic damage. CN016 protects mice against Oxaliplatin-induced peripheral neuropathy[1][2].
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CN016 | CN016 is a neuroprotective agent. CN016 inhibits the elevation of pro-inflammatory cytokines G-CSF, GM-CSF and IL-6 induced by Oxaliplatin (HY-17371). CN016 suppresses Paclitaxel (HY-B0015)-induced inflammatory responses and immune cell infiltration into sensory neurons. CN016 protects neurons from Paclitaxel (HY-B0015)-induced neurotoxic damage. CN016 protects mice against Oxaliplatin-induced peripheral neuropathy. | |||||||||||||||||||||
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- [1]. Chen YF, et al. Discovery of Potential Neuroprotective Agents against Paclitaxel-Induced Peripheral Neuropathy. J Med Chem. 2022;65(6):4767-4782. [Content Brief]
- [2]. Chen LH, et al. BDNF Val66Met protects oxaliplatin-induced peripheral neuropathy in patients with colorectal cancer. Sci Transl Med. 2026;18(837):eadx1436. [Content Brief]
Keywords
