29876-08-2
Chemical Structure
Bunitrolol hydrochloride
- CAS No.: 29876-08-2
- Formula:C14H21ClN2O2
- Molecular Weight:284.78
IUPAC Name: 2-(3-(tert-butylamino)-2-hydroxypropoxy)benzonitrile hydrochloride
InChIKey: RJPWESHPIMRNNM-UHFFFAOYSA-N
SMILES: N#CC1=CC=CC=C1OCC(CNC(C)(C)C)O.Cl
Biological Activity: Bunitrolol hydrochloride is an orally active β-adrenergic blocker that has a high affinity for β-adrenergic receptors. Bunitrolol hydrochloride exerts significant β-receptor antagonist activity and has weak α1-blocking activity. Bunitrolol hydrochloride is mainly used in the study of cardiovascular diseases such as hypertension and angina pectoris, and is also used in placental transport research[1][2][3].
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Bunitrolol hydrochloride | Bunitrolol hydrochloride is an orally active β-adrenergic blocker that has a high affinity for β-adrenergic receptors. Bunitrolol hydrochloride exerts significant β-receptor antagonist activity and has weak α1-blocking activity. Bunitrolol hydrochloride is mainly used in the study of cardiovascular diseases such as hypertension and angina pectoris, and is also used in placental transport research. | |||||||||||||||||||||
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- [1]. Tsuchihashi H, et al. Effects of bunitrolol on adrenergic and serotonergic receptors. Jpn J Pharmacol. 1987 Nov;45(3):349-56. [Content Brief]
- [2]. Hasegawa Y, et al. Chronic effects of bunitrolol and pindolol on blood pressure, heart rate, vascular lesions, and plasma renin activity in hypertensive rats. Jpn J Pharmacol. 1982 Aug;32(4):742-5. [Content Brief]
- [3]. Van Petten G R, et al. Chronic preparation of the pregnant ewe and fetus for pharmacological research: the placental transfer and fetal effects of bunitrolol. Journal of Pharmacological Methods, 1978, 1(1): 45-60.
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