Bunitrolol hydrochloride
Bunitrolol hydrochloride is an orally active β-adrenergic blocker that has a high affinity for β-adrenergic receptors. Bunitrolol hydrochloride exerts significant β-receptor antagonist activity and has weak α1-blocking activity. Bunitrolol hydrochloride is mainly used in the study of cardiovascular diseases such as hypertension and angina pectoris, and is also used in placental transport research.
For research use only. We do not sell to patients.
- CAS No.: 29876-08-2
- Formula: C14H21ClN2O2
- Molecular Weight:284.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Adrenergic Receptor Isoforms
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Biological Activity
Description
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β-adrenoceptor |
Chemical Information
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CAS No. 29876-08-2
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Molecular Weight 284.78
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Formula C14H21ClN2O2
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SMILES
N#CC1=CC=CC=C1OCC(CNC(C)(C)C)O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.
Purity & Documentation
References
[1]. Tsuchihashi H, et al. Effects of bunitrolol on adrenergic and serotonergic receptors. Jpn J Pharmacol. 1987 Nov;45(3):349-56. [Content Brief]
[2]. Hasegawa Y, et al. Chronic effects of bunitrolol and pindolol on blood pressure, heart rate, vascular lesions, and plasma renin activity in hypertensive rats. Jpn J Pharmacol. 1982 Aug;32(4):742-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bunitrolol hydrochloride Related Classifications
HY-116957 Related Classifications
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