2991504-90-4
Chemical Structure
Estrogen receptor modulator 10
- CAS No.: 2991504-90-4
- Formula:C32H37F9N4O3S
- Molecular Weight:728.71
InChIKey: XXGISHVVRYYHCS-SONOPUAISA-N
SMILES: FC(C=C(NC1CN(CCCS(CCCC(F)(F)C(F)(F)F)(=O)=O)C1)C=C2F)=C2[C@H]3N(CC(F)(F)CO)[C@H](C)CC4=C3NC5=CC=CC=C54
Biological Activity: Estrogen receptor modulator 10 (compound G-5b) is an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM). Estrogen receptor modulator 10 is developed based on the Fulvestrant (HY-13636) molecule and can rapidly degrade ER receptors through the proteasome pathway. Estrogen receptor modulator 10 can induce cell apoptosis and block cells in the G1/G0 phase and can be used in cancer research[1].
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Estrogen receptor modulator 10 | Estrogen receptor modulator 10 (compound G-5b) is an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM). Estrogen receptor modulator 10 is developed based on the Fulvestrant (HY-13636) molecule and can rapidly degrade ER receptors through the proteasome pathway. Estrogen receptor modulator 10 can induce cell apoptosis and block cells in the G1/G0 phase and can be used in cancer research. | |||||||||||||||||||||
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