3032265-06-5
3032265-06-5
Chemical Structure
DEG-77
- CAS. Nr.: 3032265-06-5
- Formula:C24H21N3O6
- Molecular Weight:447.44
InChIKey: ZFAKJMUJUNDGEI-UHFFFAOYSA-N
SMILES: O=C1C2=CC=C(C=C2CN1C3CCC(NC3=O)=O)NC(C4=CC5=C(OC4)C(OC)=CC=C5)=O
Biological Activity: DEG-77 is a molecular glue targeting IKZF2 and CK1α, with DC50 values of 15.3 nM and 10 nM, respectively. DEG-77 exhibits significant anti-tumor activity, inducing increased transcriptional levels of the pro-apoptotic protein Bax and the cell cycle arrest protein p21. DEG-77 is applicable to the research of acute myeloid leukemia (AmL), diffuse large B-cell lymphoma and ovarian cancer.
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DEG-77 | 99.03% | DEG-77 is a molecular glue targeting IKZF2 and CK1α, with DC50 values of 15.3 nM and 10 nM, respectively. DEG-77 exhibits significant anti-tumor activity, inducing increased transcriptional levels of the pro-apoptotic protein Bax and the cell cycle arrest protein p21. DEG-77 is applicable to the research of acute myeloid leukemia (AmL), diffuse large B-cell lymphoma and ovarian cancer. | ||||||||||||||||||||
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