3033018-68-4
Chemical Structure
BRD9 Degrader-2
- CAS No.: 3033018-68-4
- Formula:C40H43F3N6O4S
- Molecular Weight:760.87
InChIKey: LGLQCBGPDQBRIS-RDRPBHBLSA-N
SMILES: N#C/C(C(N1CCC2=C(C1C)C=CC=C2CN3CCN(CC3)CC4=C(OC)C=C(C5=CN(C)C(C(C)=C5C)=O)C=C4OC)=O)=C\C6=NC(C(F)(F)F)=CS6
Biological Activity: BRD9 Degrader-2 is a selective BRD9 molecular glue degrader. BRD9 Degrader-2 consists of a BRD9-binding ligand, a linker, and a warhead that promotes proteasomal degradation of BRD9 via a non-canonical PROTAC mechanism independent of CRBN or VHL E3 ligases. BRD9 Degrader-2 can be used in cancer research, including studies of malignant rhabdoid tumors, specific sarcomas, and acute myeloid leukemia[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
BRD9 Degrader-2 | BRD9 Degrader-2 is a selective BRD9 molecular glue degrader. BRD9 Degrader-2 consists of a BRD9-binding ligand, a linker, and a warhead that promotes proteasomal degradation of BRD9 via a non-canonical PROTAC mechanism independent of CRBN or VHL E3 ligases. BRD9 Degrader-2 can be used in cancer research, including studies of malignant rhabdoid tumors, specific sarcomas, and acute myeloid leukemia. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
