BRD9 Degrader-2
BRD9 Degrader-2 is a selective BRD9 molecular glue degrader. BRD9 Degrader-2 consists of a BRD9-binding ligand, a linker, and a warhead that promotes proteasomal degradation of BRD9 via a non-canonical PROTAC mechanism independent of CRBN or VHL E3 ligases. BRD9 Degrader-2 can be used in cancer research, including studies of malignant rhabdoid tumors, specific sarcomas, and acute myeloid leukemia.
For research use only. We do not sell to patients.
- CAS No.: 3033018-68-4
- Formula: C40H43F3N6O4S
- Molecular Weight:760.87
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
BRD9 ≤1.25 nM (DC50) |
BRD9 Degrader-2 (Compound B11) (1 μM; 6-24 h), as a BRD9-targeting degrader, exhibits a DC50 ≤ 12.5 nM and a Dmax ≥ 75% in HiBiT-BRD9 knock-in HEK293 cells and MV4-11 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 3033018-68-4
-
Molecular Weight 760.87
-
Formula C40H43F3N6O4S
-
SMILES
N#C/C(C(N1CCC2=C(C1C)C=CC=C2CN3CCN(CC3)CC4=C(OC)C=C(C5=CN(C)C(C(C)=C5C)=O)C=C4OC)=O)=C\C6=NC(C(F)(F)F)=CS6
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BRD9 Degrader-2 Related Classifications
HY-163809 Related Classifications
Powered by Bioz