3034875-56-1
Chemical Structure
PROTAC EZH2 Degrader-35
- CAS No.: 3034875-56-1
- Formula:C66H87N13O13
- Molecular Weight:1270.48
InChIKey: MXGCBSKEUCDBPN-UHFFFAOYSA-N
SMILES: O=C(C1=CC(C2=CC=C(N3CCN(CC3)C(CCCCCCCCC4=CN(CCOCCOCCOCCOCCOCCOCCNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)N=N4)=O)N=C2)=CC8=C1C=NN8C(C)C)NCC9=C(C)C=C(C)NC9=O
Biological Activity: PROTAC EZH2 Degrader-35 (compound U3i (44)) is a PROTAC protein degrader targeting EZH2 with a human EZH2 Ka of 16.19 nM. PROTAC EZH2 Degrader-35 exhibits antiproliferative activity in triple-negative breast cancer cells and minimal cytotoxicity in normal human epithelial, hepatic, renal cells.PROTAC EZH2 Degrader-35 can be used for the research of triple-negative breast cancer[1].
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PROTAC EZH2 Degrader-35 | PROTAC EZH2 Degrader-35 (compound U3i (44)) is a PROTAC protein degrader targeting EZH2 with a human EZH2 Ka of 16.19 nM. PROTAC EZH2 Degrader-35 exhibits antiproliferative activity in triple-negative breast cancer cells and minimal cytotoxicity in normal human epithelial, hepatic, renal cells.PROTAC EZH2 Degrader-35 can be used for the research of triple-negative breast cancer. | |||||||||||||||||||||
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