3040301-46-7
3040301-46-7
Chemical Structure
HuR degrader 2
- CAS No.: 3040301-46-7
- Formula:C20H15N3O3
- Molecular Weight:345.35
InChIKey: JGYUESUFBXKHCZ-UHFFFAOYSA-N
SMILES: O=C1NC(C(C2=COC3=C2C=CC(C4=C(C=CN5)C5=NC=C4)=C3)CC1)=O
Biological Activity: HuR degrader 2 (Compound 3) is a molecule glue, which targets RNA-binding protein Hu antigen R (HuR) and degrades 30% HuR at 0.1 μM. HuR degrader 2 inhibits the proliferation of cancer cell Colo-205, with IC50≤200 nM. HuR degrader 2 exhibits a high affinity with cereblon, with an HTRF ratio < 0.02[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HuR degrader 2 | 98.47% | HuR degrader 2 (Compound 3) is a molecule glue, which targets RNA-binding protein Hu antigen R (HuR) and degrades 30% HuR at 0.1 μM. HuR degrader 2 inhibits the proliferation of cancer cell Colo-205, with IC50≤200 nM. HuR degrader 2 exhibits a high affinity with cereblon, with an HTRF ratio < 0.02. | ||||||||||||||||||||
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References
Keywords
