3044032-95-0
Chemical Structure
Zolucatetide
Synonym(s): FOG-001; I-66
- CAS No.: 3044032-95-0
- Formula:C102H134N18O25S2
- Molecular Weight:2076.39
InChIKey: QZAJMBQKMDKREN-XAAYEZHBSA-N
SMILES: O=C(N[C@@H](CC1=CSC2=C1C=CC=C2)C(N[C@@H](CCC(NCCCC[C@H](NC([C@@H](NC([C@H](C)NC(C(C)(C)NC([C@H](CC3=CC=CC(C(O)=O)=C3)NC([C@@H](N4)CC(O)=O)=O)=O)=O)=O)CC5=CC=CC=C5)=O)C6=O)=O)C(N[C@H](C(N)=O)C)=O)=O)[C@H](CC7=CSC=C7)NC([C@@]8(CCN(C(OCCC/C=C/CCC[C@](NC([C@H](CC(C)(C)C)NC([C@H](CC(O)=O)N9)=O)=O)(CCC/C=C\C[C@]%10(CCCN%10C(C)=O)C9=O)C4=O)=O)C8)N6)=O
Biological Activity: Zolucatetide (FOG-001;I-66) is a potent β-catenin inhibitor with an IC50 of <50 nM. Zolucatetide can inhibits β-catenin and T-cell factor (TCF) transcription factor interaction. Zolucatetide inhibits cell proliferation and induces cell cycle arrest in target cells. Zolucatetide exhibits anti-tumor efficacy in mice bearing COLO320DM colon cancer cell (with APC, TP53 mutations) xenografts. Zolucatetide can be used for the study of colon cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Zolucatetide | 98.47% | Zolucatetide (FOG-001;I-66) is a potent β-catenin inhibitor with an IC50 of <50 nM. Zolucatetide can inhibits β-catenin and T-cell factor (TCF) transcription factor interaction. Zolucatetide inhibits cell proliferation and induces cell cycle arrest in target cells. Zolucatetide exhibits anti-tumor efficacy in mice bearing COLO320DM colon cancer cell (with APC, TP53 mutations) xenografts. Zolucatetide can be used for the study of colon cancer. | ||||||||||||||||||||
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Keywords
