3055162-52-9
Chemical Structure
AANAT-IN-1
- CAS No.: 3055162-52-9
- Formula:C27H19FN2O4S2
- Molecular Weight:518.58
InChIKey: RQYKFUOVFMVXSF-VHXPQNKSSA-N
SMILES: FC1=CC=C(C=C1)CN2C(/C(C3=C2C=CC=C3)=C4SC(N(CC5=CC=C(CC(O)=O)C=C5)C\4=O)=S)=O
Biological Activity: AANAT-IN-1 is an arylalkylamine N-acetyltransferase (AANAT) inhibitor with a sheep AANAT IC50 of 9.9 μM. AANAT-IN-1 binds to the active site of sheep AANAT, interacting with amino acid residues via hydrogen bonds, hydrophobic interactions, ionic interactions, and water bridges, inhibiting the enzyme's catalytic activity. AANAT-IN-1 can be used for the researches of circadian rhythm-associated neuropsychiatric conditions, seasonal affective disorder, and other diseases associated with abnormally elevated melatonin levels[1].
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AANAT-IN-1 | 99.87% | AANAT-IN-1 is an arylalkylamine N-acetyltransferase (AANAT) inhibitor with a sheep AANAT IC50 of 9.9 μM. AANAT-IN-1 binds to the active site of sheep AANAT, interacting with amino acid residues via hydrogen bonds, hydrophobic interactions, ionic interactions, and water bridges, inhibiting the enzyme's catalytic activity. AANAT-IN-1 can be used for the researches of circadian rhythm-associated neuropsychiatric conditions, seasonal affective disorder, and other diseases associated with abnormally elevated melatonin levels. | ||||||||||||||||||||
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Keywords
