305866-70-0
Chemical Structure
MBA-m1
- CAS No.: 305866-70-0
- Formula:C27H21ClN2O2
- Molecular Weight:440.92
IUPAC Name: N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-6-methoxy-2-methylquinolin-4-amine
InChIKey: XMCGZKAHUKOWQN-UHFFFAOYSA-N
SMILES: ClC1=CC(NC2=CC(C)=NC3=C2C=C(OC)C=C3)=CC=C1OC4=CC5=C(C=CC=C5)C=C4
Biological Activity: MBA-m1 is a reversible non-covalent allosteric inhibitor of mMLKL2, with a Kd value of 6 μM for mMLKL2. MBA-m1 delays Necroptosis. MBA-m1 has no effect on the activities of RIPK1 or RIPK3. MBA-m1 alleviates skin injury, epidermal thickening and immune cell infiltration in dermatitis models, and reduces aortic diameter enlargement and structural changes in abdominal aortic aneurysm models. MBA-m1 can be used in research related to dermatitis and abdominal aortic aneurysm[1][2].
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MBA-m1 | 98.20% | MBA-m1 is a reversible non-covalent allosteric inhibitor of mMLKL2, with a Kd value of 6 μM for mMLKL2. MBA-m1 delays Necroptosis. MBA-m1 has no effect on the activities of RIPK1 or RIPK3. MBA-m1 alleviates skin injury, epidermal thickening and immune cell infiltration in dermatitis models, and reduces aortic diameter enlargement and structural changes in abdominal aortic aneurysm models. MBA-m1 can be used in research related to dermatitis and abdominal aortic aneurysm. | ||||||||||||||||||||
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- [1]. Ros U, et al. MLKL activity requires a splicing-regulated, druggable intramolecular interaction. Molecular cell. 2025 Apr 17;85(8):1589-1605.e12. [Content Brief]
- [2]. Abdelwahab Y. Development of a New Class of Necroptosis Inhibitors That Bind Allosterically to Human and Mouse MLKL[D]. Universität zu Köln, 2025.
Keywords
