3065634-19-4
Chemical Structure
RIPK1-IN-34
- CAS No.: 3065634-19-4
- Formula:C28H25N7O2
- Molecular Weight:491.54
InChIKey: NADGIMFCUNTYJK-INIZCTEOSA-N
SMILES: O=C(C1=C2C=C(C3=CC4=NC(NC(C5CC5)=O)=NN4C=C3)C=CC2=NC(C)=N1)N[C@H](C6=CC=CC=C6)C
Biological Activity: RIPK1-IN-34 is a selective, brain-penetrant RIPK1 inhibitor (IC50 = 126.70 nM) with almost no inhibitory effect on RIPK3 (IC50 ＞ 10, 000 nM). RIPK1-IN-34 offers substantial neuroprotection by inhibiting the phosphorylation of RIPK1, RIPK3, and mixed lineage kinase domain-like pseudokinase (MLKL) within the necroptosis pathway. RIPK1-IN-34 shows the neuroprotective effect in a rat middle cerebral artery occlusion (MCAO) model. RIPK1-IN-34 can be used for the study of anti-acute ischemic stroke (AIS)[1].
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RIPK1-IN-34 | RIPK1-IN-34 is a selective, brain-penetrant RIPK1 inhibitor (IC50 = 126.70 nM) with almost no inhibitory effect on RIPK3 (IC50 ＞ 10, 000 nM). RIPK1-IN-34 offers substantial neuroprotection by inhibiting the phosphorylation of RIPK1, RIPK3, and mixed lineage kinase domain-like pseudokinase (MLKL) within the necroptosis pathway. RIPK1-IN-34 shows the neuroprotective effect in a rat middle cerebral artery occlusion (MCAO) model. RIPK1-IN-34 can be used for the study of anti-acute ischemic stroke (AIS). | |||||||||||||||||||||
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Keywords
