3066447-73-9
Chemical Structure
RIPK2-IN-9
- CAS No.: 3066447-73-9
- Formula:C26H30F2N6O
- Molecular Weight:480.55
InChIKey: KLSZPZJLCGFRCQ-RPWUZVMVSA-N
SMILES: CC1=CC(F)=C(C(NC2CC2)=O)C=C1N3C=C(C4=CN=CC(N[C@@H]5[C@@H](CN(CC5)CC)F)=C4)C=N3
Biological Activity: RIPK2-IN-9 is a RIPK2 inhibitor with an IC50 < 2.5 nM. RIPK2-IN-9 inhibits NOD2-mediated NF-κB signaling and the protein-protein interaction between RIPK2 and XIAP, and inhibits NOD2 ligand-induced TNF-α secretion in human whole blood. RIPK2-IN-9 exhibits low inhibitory activity against the hERG channel. RIPK2-IN-9 can be used for research on RIPK2-related inflammatory diseases such as inflammatory bowel disease and rheumatoid arthritis[1].
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RIPK2-IN-9 | RIPK2-IN-9 is a RIPK2 inhibitor with an IC50 < 2.5 nM. RIPK2-IN-9 inhibits NOD2-mediated NF-κB signaling and the protein-protein interaction between RIPK2 and XIAP, and inhibits NOD2 ligand-induced TNF-α secretion in human whole blood. RIPK2-IN-9 exhibits low inhibitory activity against the hERG channel. RIPK2-IN-9 can be used for research on RIPK2-related inflammatory diseases such as inflammatory bowel disease and rheumatoid arthritis. | |||||||||||||||||||||
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