3080963-58-9
3080963-58-9
Chemical Structure
Neladalkib-d3
Synonym(s): NVL-655-d3; NUV-655-d3
- CAS No.: 3080963-58-9
- Formula:C23H19D3ClFN6O
- Molecular Weight:455.93
InChIKey: FWZSCAQEBTVTOM-BYXJFACLSA-N
SMILES: C[C@H](C1=CC(F)=CC=C1C2=NN(C([2H])([2H])[2H])C=C2CC3=C4N(CC)N=C3Cl)OC5=C(N)N=CC4=C5
Biological Activity: Neladalkib-d3 (NVL-655-d3) is the deuterium labeled Neladalkib (HY-156467). Neladalkib (NVL-655) is an oral ALK inhibitor, the IC50 for Neladalkib in inhibiting ALK is 2.8 nM. Neladalkib promotes cell apoptosis and has anti-tumor activity.
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Neladalkib-d3 | Neladalkib-d3 (NVL-655-d3) is the deuterium labeled Neladalkib (HY-156467). Neladalkib (NVL-655) is an oral ALK inhibitor, the IC50 for Neladalkib in inhibiting ALK is 2.8 nM. Neladalkib promotes cell apoptosis and has anti-tumor activity. | |||||||||||||||||||||
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Neladalkib | 99.87% | Neladalkib (NVL-655) is an oral ALK inhibitor, the IC50 for Neladalkib in inhibiting ALK is 2.8 nM. Neladalkib promotes cell apoptosis and has anti-tumor activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.74
HY-152292Zidesamtinib -
Similarity Score 0.55
HY-12215Lorlatinib -
Similarity Score 0.55
HY-12215S2Deulorlatinib -
Similarity Score 0.53
HY-135509Lorlatinib acetate -
Similarity Score 0.47
HY-122601TAM-IN-1 -
Similarity Score 0.44
HY-139611Navlimetostat -
Similarity Score 0.44
HY-139611B(S)-Navlimetostat -
Similarity Score 0.44
HY-17675Lorlatinib impurity-1 -
Similarity Score 0.44
HY-101798MDVN1003 -
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