2. Protein Tyrosine Kinase/RTK
  3. TAM Receptor
  4. TAM-IN-1

TAM-IN-1 (compound 1) is a potent macrocyclic inhibitor of Axl and Mer, with Kis of 130 pM and <50 pM, respectively.

For research use only. We do not sell to patients.

TAM-IN-1

TAM-IN-1 Chemical Structure

CAS No. : 1454847-05-2

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TAM-IN-1 Related Antibodies

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Axl Mer Tyro3

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Description

TAM-IN-1 (compound 1) is a potent macrocyclic inhibitor of Axl and Mer, with Kis of 130 pM and <50 pM, respectively[1].

IC50 & Target

Axl

130 pM (Ki)

Mer

<50 pM (Ki)

Molecular Weight

460.89

Formula

C21H22ClFN6O3
CAS No.
SMILES

OCCN1C2=C(C(C)=N1)C3=CN=C(N)C(O[C@@H](C4=C(Cl)C(F)=CC=C4C(N(C2)C)=O)C)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TAM-IN-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAM-IN-11454847-05-2TAM ReceptorTyro3AxlMermacrocyclicInhibitorinhibitorinhibit

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HY-122601
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