3082173-75-6
3082173-75-6
Chemical Structure
Polθ-IN-11
- CAS No.: 3082173-75-6
- Formula:C24H18FN5O3Se
- Molecular Weight:522.39
InChIKey: OJYLDJBNNHIVGR-UHFFFAOYSA-N
SMILES: COC1=CC=CC(F)=C1C2=C(C=NC(C)=C2)C(NC3=NN=C([Se]3)COC4=CC=C(C=C4)C#N)=O
Biological Activity: Polθ-IN-11 is an orally active DNA polymerase θ (Polθ) ATPase inhibitor with an IC50 of 4.3 nM against human targets. Polθ-IN-11 activates the cGAS-STING pathway. Polθ-IN-11 upregulates the expression of PD-L1 in HR-deficient cancer cells. Polθ-IN-11 acts synergistically with PARP inhibition in HR-deficient cancer cells and in vivo xenograft models. Polθ-IN-11 can be used in studies related to HR-deficient cancers[1].
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Polθ-IN-11 | Polθ-IN-11 is an orally active DNA polymerase θ (Polθ) ATPase inhibitor with an IC50 of 4.3 nM against human targets. Polθ-IN-11 activates the cGAS-STING pathway. Polθ-IN-11 upregulates the expression of PD-L1 in HR-deficient cancer cells. Polθ-IN-11 acts synergistically with PARP inhibition in HR-deficient cancer cells and in vivo xenograft models. Polθ-IN-11 can be used in studies related to HR-deficient cancers. | |||||||||||||||||||||
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