3097167-82-0
3097167-82-0
Chemical Structure
Bfl-1-IN-5
- CAS No.: 3097167-82-0
- Formula:C24H24F3N3O2
- Molecular Weight:443.46
InChIKey: XUNQZBSJKCTTNE-RRMPHLOHSA-N
SMILES: C=CC(N(C1=CC=C(O[C@H]2C[C@H](N)CC2)C=C1)[C@H](C3=CC=C(C(F)(F)F)C(C#N)=C3)C)=O
Biological Activity: Bfl-1-IN-5 is a covalent and selective Bfl-1 inhibitor with an IC50 of 22 nM. Bfl-1-IN-5 shows selectivity for Bfl-1 over Bcl-xl, Bcl-2 and Mcl-1. Bfl-1-IN-5 induces caspase-3/7 activation, reduces the viability of Bfl-1-expressing lymphoma cells in combination with an Mcl-1 inhibitor, and binds covalently to intracellular Bfl-1. Bfl-1-IN-5 can be used for lymphoma research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Bfl-1-IN-5 | 99.24% | Bfl-1-IN-5 is a covalent and selective Bfl-1 inhibitor with an IC50 of 22 nM. Bfl-1-IN-5 shows selectivity for Bfl-1 over Bcl-xl, Bcl-2 and Mcl-1. Bfl-1-IN-5 induces caspase-3/7 activation, reduces the viability of Bfl-1-expressing lymphoma cells in combination with an Mcl-1 inhibitor, and binds covalently to intracellular Bfl-1. Bfl-1-IN-5 can be used for lymphoma research. | ||||||||||||||||||||
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