3104736-80-0
Chemical Structure
LUF7996
- CAS No.: 3104736-80-0
- Formula:C39H34Cl2F3N5O8S
- Molecular Weight:860.68
InChIKey: RFHLRRLBVWDPOD-UHFFFAOYSA-N
SMILES: ClC1=CC=C(OC2=CC=C(C(NCCCCCCNC3=CC=CC(C(N4C5CCC(NC5=O)=O)=O)=C3C4=O)=O)C=C2)C(NS(C6=CC=C(Cl)C(C(F)(F)F)=C6)(=O)=O)=C1
Biological Activity: LUF7996 is a CCR2 PROTAC Degrader degrading CCR2 with DC50 = 2.6 μM. LUF7996 demonstrates engagement of both and the E3 ligase cereblon and displays sustain and concentration-dependent degradation of CCR2. LUF7996 reliance on the lysosomal pathway to induce CCR2 degradation. LUF7996 efficiently inhibits monocyte migration in virto[1].
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LUF7996 | LUF7996 is a CCR2 PROTAC Degrader degrading CCR2 with DC50 = 2.6 μM. LUF7996 demonstrates engagement of both and the E3 ligase cereblon and displays sustain and concentration-dependent degradation of CCR2. LUF7996 reliance on the lysosomal pathway to induce CCR2 degradation. LUF7996 efficiently inhibits monocyte migration in virto. | |||||||||||||||||||||
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Keywords
